Newer Treatments in Long Covid

Metformin reduces long Covid incidence by 41% with just working up to 3/day

Bramante, Carolyn T., et al. “Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT): a multicentre, randomised, quadruple-blind, parallel-group, phase 3 trial.” The Lancet Infectious Diseases 23.10 (2023): 1119-1129.

https://experts.umn.edu/en/publications/outpatient-treatment-of-covid-19-and-incidence-of-post-covid-19-c

The metformin dose was titrated over 6 days:

500 mg on day 1,
500 mg twice daily on days 2–5,
then 500 mg in the morning and 1000 mg in the evening up to day 14

Yeast/Candida overgrowth is seen in severe covid and article suggests this is a potential target for long covid:

Kusakabe, Takato, et al. “Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19.” Nature Immunology (2023): 1-11.

https://www.nature.com/articles/s41590-023-01637-4

Comment – I treat the yeast malassezia with two weeks of fluconazole and the same could be used for candida as it is over the counter. Metformin has many health benefits and helps reduce pains so I took for years.

addendum – Hyperbaric Oxygen:

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