Please visit my old site which has over innovative 950 blog notes -just restarting and also eventially mirroring now: painmuse.org
A 5° lateral heel tilt (comes out to about 5 mm lateral height) has been tried many times with mediocre results. They made it more likely by eliminating those with partellofemoral issues, and demanding a 2% reduction in KAM =external knee adduction moment (markers and 3d analysis needed for that). Still, drop in pain was […]
Isolated Lumbar Disc Disease Can be Determined by Non-Invasive Magnetic Resonance Spectroscopy (MRS) and Responds to Surgery. Non-Invasive Magnetic Resonance Spectroscopy scans for certain disc chemicals- lactate (LA) and proteoglycan (PG), as quantifiable biomarkers for discogenic pain. It was found to have “total accuracy of 85%, sensitivity of 82%, and specificity of 88%. These increased to 93%, 91%, and 93%
respectively, in non-herniated discs” – when compared to provocative discography (PD). Surgery to positive discs made it practical: :”when all MRS positive discs were treated, surgical success was 97% versus 57% when the treated level was MRS negative, or 54% when the non-treated adjacent level was MRS positive.”
Yeast like germs found in facial seborrhea (Malassezia and Candida species), and other fungi have been found in brains of alzheimer victims. Prior untreated facial cold sores increase dementia rate 3-10 fold. The beta amyloid we were so worried about is toxic to these organism and now thought to be just a protective agent. Mouse model of alzheimer’s is now shown to get candida granulomas in the brain. Very quickly there may be a paradigm shift of thinking of alzheimer causes from brain crud problem to infection. Researchers have also found an agent to interfere with prion virus like particles found in dementia.
40 mg Depo Medrol into tender TMJ was no better off a month later than saline injection. The crystals of the steroid made 5 subjects temporarily worse which they pegged as very bad “adverse events”.
It looks like the only agents to maybe survive are topical amitriptyline and gabapentin and hormones estrogen and testosterone.
It is commonly taught that drug combinations should be used in chronic pain – the most common pain being chronic back pain. Now it has been shown that little is gained from that. Only combo worth mentioning was buprenorphine plus pregabalin – the former is difficult if insurers won’t cover. There are other options that require actually treating the patient.
Analysis of 3 country surgery stats for spinal stenosis found a 77% one year response rate but no benefit from fusion.