Melatonin Attenuates Stress But There is Something Fishy About It

Melatonin can induce sleep and reduce cortisone stress but this was done in Zebra Fish… Lunkes LC, Paiva IM, Egger RC, Braga WF, Alvarez-Leite JI, da Cunha Barreto-Vianna AR, Murgas LDS. Melatonin administration attenuates acute stress by inducing sleep state in zebrafish (Danio rerio). Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr 7;246:109044. “Melatonin […]

Yes, Colchicine Does Prevent Allopurinol Flare-ups in 1st 6 Months Gout RX

Standard practice is to add colchicine to allopurinol in first 6 months of gout treatment.  Allopurinol treatment dissolves crystals of uric acid which can irritate tissues in that process. ” Subjects treated with colchicine experienced fewer total flares (0.52 vs 2.91, p = 0.008), fewer flares from 0 to 3 months (0.57 vs 1.91, p = 0.022), fewer flares 3–6 months (0 vs 1.05, p = 0.033), less severe flares as reported on VAS (3.64 vs 5.08, p =0.018), and fewer recurrent gout flares (p = 0.001). Colchicine was well tolerated.”

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Antidepressants do not Help Neck or Back Pain

Re older antidepressants  – A metanalysis of studies concluded the benefits were “small”Salerno, Stephen M., Robert Browning, and Jeffrey L. Jackson. “The effect of antidepressant treatment on chronic back pain: a meta-analysis.” Archives of Internal Medicine 162.1 (2002): 19-24.“In conclusion, adjunct antidepressant therapy at doses therapeutic for depression is associated with a small but significant […]