Lupus being a single gene defect and new evidence of Sick Mitochondria spilling out DNA fragments changes the complete face of autoimuune diseases. Am shocked.
Autoimmunity is taking a completely new twist:
– Lupus has been linked dysregulation of immune response related to one gene which causes body to fight its own DNA rather than viral ones:
Lupus trigger discovered: Researchers were able to trace a form of the autoimmune disease lupus back to a single mutation
https://www.mpg.de/21374791/lupus-trigger
——————-
Multiple Immune dysregulations have been linked to sick mitochondria (energy organelles in cells) spilling out DNA fragments into the body.
Scientists reveal how our cells’ leaky batteries are making us sick
https://www.eurekalert.org/news-releases/1036149
Newman, L.E., Weiser Novak, S., Rojas, G.R. et al. Mitochondrial DNA replication stress triggers a pro-inflammatory endosomal pathway of nucleoid disposal. Nat Cell Biol 26, 194–206 (2024).
https://www.nature.com/articles/s41556-023-01343-1
Interesting, the first indication of mitochondria spilling DNA fragments was an article some months ago related to Parkinson’s disease:
News Release 2-Oct-2023 Researchers find a cause of Parkinson’s disease
https://www.eurekalert.org/news-releases/1003348
These articles have just blown my mind and I don’t know what to think of autoimmunity anymore.
newpainmuse 