Melatonin can induce sleep and reduce cortisone stress but this was done in Zebra Fish… Lunkes LC, Paiva IM, Egger RC, Braga WF, Alvarez-Leite JI, da Cunha Barreto-Vianna AR, Murgas LDS. Melatonin administration attenuates acute stress by inducing sleep state in zebrafish (Danio rerio). Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr 7;246:109044. https://pubmed.ncbi.nlm.nih.gov/33838315/ “Melatonin […]
Pain Before Vomiting 96% Sensitive but Only 17% Specific in Appendicitis
Am J Emerg Med. 2021 Mar;41:84-89.doi: 10.1016/j.ajem.2020.12.066. Epub 2020 Dec 28.Is “pain before vomiting” useful?: Diagnostic performance of the classic patient history item in acute appendicitisToshihiko Takad et al Comment – Finding pain before vomiting helps with the diagnosis but can miss 5/6 cases if absent.
Chronic Severe Failed neck Surgery Pains
I have seen a case that I read in:
I have 4 patients that she is a composite of so I’d like to go over what made a difference to them. Most of the treatments are out of the box treatments that can be helpful.
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Yes, Colchicine Does Prevent Allopurinol Flare-ups in 1st 6 Months Gout RX
Standard practice is to add colchicine to allopurinol in first 6 months of gout treatment. Allopurinol treatment dissolves crystals of uric acid which can irritate tissues in that process. ” Subjects treated with colchicine experienced fewer total flares (0.52 vs 2.91, p = 0.008), fewer flares from 0 to 3 months (0.57 vs 1.91, p = 0.022), fewer flares 3–6 months (0 vs 1.05, p = 0.033), less severe flares as reported on VAS (3.64 vs 5.08, p =0.018), and fewer recurrent gout flares (p = 0.001). Colchicine was well tolerated.”
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Antidepressants do not Help Neck or Back Pain
Re older antidepressants – A metanalysis of studies concluded the benefits were “small”Salerno, Stephen M., Robert Browning, and Jeffrey L. Jackson. “The effect of antidepressant treatment on chronic back pain: a meta-analysis.” Archives of Internal Medicine 162.1 (2002): 19-24.“In conclusion, adjunct antidepressant therapy at doses therapeutic for depression is associated with a small but significant […]
Excessive sweating in buttock/groin area called Perineal Hyperhidrosis can be embarrassing and I’ve seen recent request for advice re this.
Poverty Impacts Pain
“Pain was experienced by over-indebted individuals more frequently (71.3%) compared to the general population (59.6%)”. They found opioid use was less but this would not work where I am as poor have drugs mostly covered by government.
Head and Neck Neuralgia Sites
Came across a book that gives great pics of Neuralgia sites.
Trescot, Andrea M., and FIPP ABIPP, eds.
Peripheral nerve entrapments: clinical diagnosis and management.
Alcoholism- ?Ketamine Benefits
Article suggests ketamine makes one forget drinking habits and may help abstinence. Depression element could be controlled but not the state where one thinks one can handle anything so can just have one…
Pancreatic Cancer – fungal and Mast Cell connection
Malassezia is well known for its association with facial skin rash Seborrheic Dermatitis. It has been found teaming around pancreatic cancer tissue in mice and humans and there is even the suggestion it might be oncogenic. Mast cell are found around pancreatic cancer cells as well, and a ketotifen, a drug to control mast cell degranuation, might help in pain control. Pancreatic cancer tends to occur in cases who had previous pancreatic issues and diabetes, smokers and ppi users; prophylactic metformin could reduce those chances by over 50%
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