Given Vit D3 (100ug = 4000 IU/day), subjects got reduced levels of migraines that took 3 months to be effective.
Gazerani, P., et al.
A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D3 supplementation in adult patients with migraine.
Current Medical Research and Opinion just-accepted (2018): 1-22 in press
https://www.tandfonline.com/doi/abs/10.1080/03007995.2018.1519503
- 24 cases in Vit D3 100ug = 4000 IU or placebo
- with meds, blood vit D3 levels were 87.43±32.00 nmol/l vs placebo 78.96±30.86 nmol/l
Results:
Comment –
- recent evidence suggests 8000 IU/day Vit D3 is optimal with blood levels over 100 nmol/l.
Prev Med Public Health. 2017 Jul; 50(4): 278–281. The Big Vitamin D Mistake. Dimitrios T. Papadimitriou
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541280/ - study did not achieve over 100 nmol/l blood levels
- It took 3 months to show results that would have been much quicker with 8000iu/day
- I use Osto-D2 50,000 IU Vitamin D2 once weekly – which would come to 7500 iu/day
- Interesting how placebo effect works – good initial month but wears off after
- So previous studies finding improvements in pain, back pain and now migraines with vit D were more likely related to sub-optimal doses.
addendum:
Recent study found it helped back pain in those:
- deficient in vit D (ie many darker skinned immigrants)
- more obese subjects
J Steroid Biochem Mol Biol. 2018 Sep 7. pii: S0960-0760(18)30435-7. doi:
10.1016/j.jsbmb.2018.09.005. [Epub ahead of print]
Vitamin D supplementation may improve back pain disability in vitamin D deficient
and overweight or obese adults.
Brady SRE et al
https://www.ncbi.nlm.nih.gov/pubmed/30201225
