Early Osteonecrosis Hip Helped by IV Pamidronate

When I see Osteonecrosis cases, I’ve always wondered if IV Biphosphonates could have helped. Apparently so, for this 27 year old. They used Pamidronate 45 mg daily for 3 days monthly. Only did 2 cycles and got good results.


Open Rheumatol J. 2018 Aug 29;12:125-128. doi: 10.2174/1874312901812010125.
Pamidronate Treatment of Osteonecrosis of the Hip in Young Male.
Lo Gullo A et al
https://www.ncbi.nlm.nih.gov/pubmed/30197706

  • 27 year old with prior oral steroid use
  • pain and dysmobility for 4 months
  • pamidronate 45 mg for three consecutive days every four weeks – two cycles (planned more but had thrombotic problems)
  • at 3 months near full recovery

Comment – they make a point in saying it has to be early osteonecrosis but it wasn’t that early if he had pain for 4 months. Worth a try.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.