Early Osteonecrosis Hip Helped by IV Pamidronate

When I see Osteonecrosis cases, I’ve always wondered if IV Biphosphonates could have helped. Apparently so, for this 27 year old. They used Pamidronate 45 mg daily for 3 days monthly. Only did 2 cycles and got good results.

Open Rheumatol J. 2018 Aug 29;12:125-128. doi: 10.2174/1874312901812010125.
Pamidronate Treatment of Osteonecrosis of the Hip in Young Male.
Lo Gullo A et al

  • 27 year old with prior oral steroid use
  • pain and dysmobility for 4 months
  • pamidronate 45 mg for three consecutive days every four weeks – two cycles (planned more but had thrombotic problems)
  • at 3 months near full recovery

Comment – they make a point in saying it has to be early osteonecrosis but it wasn’t that early if he had pain for 4 months. Worth a try.

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