COMT Gene Influences Opioid Use

In seeing chronic pain pateints one is left with feeling there is more to it the just structural problems. Now a single gene variant show its effects.

Pain. 2018 Sep 11. doi: 10.1097/j.pain.0000000000001400. [Epub ahead of print]
Associations of catechol-O-methyltransferase (rs4680) Single Nucleotide Polymorphisms with Opioid Use and Dose Among Adults with Chronic Pain.
Hooten WM

  • COMT has bee implicated is pain sensitivity for some time.
  • single nucleotide polymorphism
  • “Met/Met genotype was more likely to use opioids compared to the Val/Met genotype (P = 0.0089)”
  • “A post-hoc comparison demonstrated that the Val/Met (P = 0.019) and Met/Met (P = 0.043) genotypes used greater MED compared to the Val/Val genotype”

Comment – “There are more things in heaven and earth, Horatio,
Than are dreamt of in your philosophy. ” – a new layer of pain factor not thought of before.

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