New Pain Relief Target in Pancreatic Cancer

In animal model of pancreatic cancer, mast allergy/immune cells congregate around pancreatic cancer cells and their degranulation induces pain. Inhibiting mast cell function with ketotifen gives relief in a dose related fashion. Might this help pancreatitic cancer pain?


J Mol Neurosci. 2019 Oct;69(2):235-245. doi: 10.1007/s12031-019-01352-6.
Inhibition of Mast Cell Degranulation Relieves Visceral Hypersensitivity Induced
by Pancreatic Carcinoma in Mice.
Yu D et al
https://www.ncbi.nlm.nih.gov/pubmed/31201657

  • Well known that mast cell degranulation is related to Irritable bowel and peripheral sensitization in general
  • “levels of mast cell degranulation products, including tryptase, histamine, and nerve growth factor, were significantly increased in pericarcinoma tissues relative to their levels in normal controls.”
  • “mast cell stabilizer ketotifen dose-dependently alleviated pancreatic cancer pain. “

Comment  – ketotifen or trade name Zaditen is a rarely used antihistamine product; might try in in pancreatic ca and chronic abdominal pain issues though is not cheap. Dose is 1 mg twice daily

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