Melatonin can induce sleep and reduce cortisone stress but this was done in Zebra Fish…
Lunkes LC, Paiva IM, Egger RC, Braga WF, Alvarez-Leite JI, da Cunha Barreto-Vianna AR, Murgas LDS.
Melatonin administration attenuates acute stress by inducing sleep state in zebrafish (Danio rerio).
Comp Biochem Physiol C Toxicol Pharmacol. 2021 Apr 7;246:109044.
“Melatonin was able to modulate acute stress effects on zebrafish by inhibiting cortisol increasing levels, reducing locomotor parameters, inducing a sleep state, reducing lipid peroxidation and stimulating antioxidant enzymatic activity.”
Doesn’t help sleep efficacy that much (2-7%)
But gets you to sleep a little faster(2-20 min)
Helps cancer little bit:
Shiu, Stephen YW.
Towards rational and evidence‐based use of melatonin in prostate cancer prevention and treatment.
Journal of pineal research 43.1 (2007): 1-9.
Sanchez-Barcelo, Emilio J., et al.
Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation.
Expert opinion on investigational drugs 21.6 (2012): 819-831.
Li, Ya, et al.
Melatonin for the prevention and treatment of cancer.
Oncotarget 8.24 (2017): 39896.
Melatonin has been shown to help irritable bowel syndrome:
Siah KT, Wong RK, Ho KY.
Melatonin for the treatment of irritable bowel syndrome.
World J Gastroenterol. 2014 Mar 14;20(10):2492-8
I take melatonin 15 mg hs for its anti-cancer effects and it does help sleep and irritable bowel some as well…