Mild Covid Treatments

There are now medications for high risk or unvaccinated patients; I will not go into them. I will discuss other medications I have put in place for myself (71) and vaccinated. Sorry, Ivermectin (horse dewormer) is not on my list. They include vitamin D 50,000 u/day, fluoxamine 50 -100 mg twice daily, colchicine 0.5 mg twice daily, and L-arginine 1000 mg three times daily.

Vitamin D:
High does vitamin d did make a difference albeit it could be in deficient cases most so:

Rastogi, Ashu, et al. “Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study).” Postgraduate medical journal 98.1156 (2022): 87-90.
https://pmj.bmj.com/content/98/1156/87.abstract

They used 60,000 units vitamin D3 for 7 days.

“in intervention and control group, respectively]. 10 (62.5%) participants in the intervention group and 5 (20.8%) participants in the control arm (p<0.018) became SARS-CoV-2 RNA negative.”

I would take 50,000 units/day for at least 7 days then maybe 5000 u/day

 Fluvoxamine
– Probably the most promising agent but has most side effects

– “Clinicians who prescribe fluvoxamine for COVID-19 should familiarize themselves with relative contraindications and notable drug-drug interactions, including the need to limit caffeine (eTable 2 in the Supplement). The most common reported side effects from fluvoxamine in clinical trials are gastrointestinal (nausea, vomiting, diarrhea, and anorexia) and central nervous system complaints (headache, dizziness, somnolence, and nervousness).”

 

both of these trials are using 50 mg twice daily of fluvoxamine, which, if unsuccessful, could indicate that 100 mg twice daily is the minimum effective dose.”

‘Depending on the scenario, the probability of any association with reduced hospitalization ranged from 94.1% to 98.6%, and the probability of moderate association ranged from 81.6% to 91.8%.’

WOW, that is impressive

https://jamanetwork.com/journals/jamanetworkopen/article-abstract/2790742

 

Arginine

– health food store amino acid so safe

 – dose was 1.66 g L-arginine twice a day or about three of the 1000 mg/day

“At 10-day evaluation, 71.1% of patients in the L-arginine arm and 44.4% in the placebo arm (p < 0.01) had the respiratory support reduced” which was quite significant

https://www.sciencedirect.com/science/article/pii/S2589537021004053

 Colchicine

 Review of it are rather mediocre but:

– safe

-decreased covid severity so good there

– no difference in hospitalization

review here: 

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0266245

Vitamin C

Milani, Gregorio Paolo, Marina Macchi, and Anat Guz-Mark.
Vitamin C in the Treatment of COVID-19.
Nutrients 13.4 (2021): 1172.
https://www.mdpi.com/2072-6643/13/4/1172/pdf
 
Hard evidence for oral is not too strong but often used in severer cases. Nothing wrong in taking 500 – 1000 mg twice daily for 7 days.

Comment – have these agents in the frig; if you can think of others that could be used, please advise

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