Chronic Prostatism Pain Could be Colonization of Painful Bacteria

Gram positive bacteria in prostatic secretions of patient with male chronic pelvic pain syndrome – inoculated into uretra of rats can induce chronic pelvic pain in them.

Prostate. 2019 Feb;79(2):160-167. doi: 10.1002/pros.23721
Role of gram-positive bacteria in chronic pelvic pain syndrome (CPPS).
Murphy SF et al

  • chronic prostatism  with pelvic pain – prevalence of 7.3% males
  • pain in the pelvic and genital regions extending occasionally
    into the abdomen. Lower urinary tract dysfunction assocated.
  • notable decreased quality of life
  • deemed noninfectious though small numbers of bacteria ore isolated from secretions
  • “appreciable levels of clinical benefit have been observed following fluoroquinolone antimicrobial treatment”


Both Cp1 E. coli and gram positive organisms for chronic prostatism prostatic secretions – if inoculated into urethra of mice, can induce a chronic pain syndrome while prostatitic  germs from health males subjects transferred,  do not.

Most likely bad strains were:

  • 7244 Staph epidermidis
  • 2551 Strep. haemolyticus – most now plain amocillin resistant
  • 427 Enterococcus. faecalis. – needs  amocillin or clavulin though could be multi drug resistant

Concluded that chronic prostatism could be a “dysbiosis of the prostate microflora”

Comment – sensitivity of these organism is severely limited. So try Levofloxin, and is this doesn’t work Clavulin – beyond that, you’d need an infectious disease expert to open up uses for vancomycin etc. Oddly, sensitivity to sulfa is increasing due to lack of use.

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