Gram positive bacteria in prostatic secretions of patient with male chronic pelvic pain syndrome – inoculated into uretra of rats can induce chronic pelvic pain in them.
Prostate. 2019 Feb;79(2):160-167. doi: 10.1002/pros.23721
Role of gram-positive bacteria in chronic pelvic pain syndrome (CPPS).
Murphy SF et al
- chronic prostatism with pelvic pain – prevalence of 7.3% males
- pain in the pelvic and genital regions extending occasionally
into the abdomen. Lower urinary tract dysfunction assocated.
- notable decreased quality of life
- deemed noninfectious though small numbers of bacteria ore isolated from secretions
- “appreciable levels of clinical benefit have been observed following fluoroquinolone antimicrobial treatment”
Both Cp1 E. coli and gram positive organisms for chronic prostatism prostatic secretions – if inoculated into urethra of mice, can induce a chronic pain syndrome while prostatitic germs from health males subjects transferred, do not.
Most likely bad strains were:
- 7244 Staph epidermidis
- 2551 Strep. haemolyticus – most now plain amocillin resistant
- 427 Enterococcus. faecalis. – needs amocillin or clavulin though could be multi drug resistant
Concluded that chronic prostatism could be a “dysbiosis of the prostate microflora”
Comment – sensitivity of these organism is severely limited. So try Levofloxin, and is this doesn’t work Clavulin – beyond that, you’d need an infectious disease expert to open up uses for vancomycin etc. Oddly, sensitivity to sulfa is increasing due to lack of use.