PBS is fraught with problems related to “heterogeneity” – some a neurologically based and some are inflammatory based for example. Finding any measure to work is a difficulty in dealing with “subtypes’. What we do know at this stage is the those with Hunner’s ulcer lesions in bladder(blood in urine would suggest it), would benefit from fulguration. A new innovation is an anti – tumor necrosis factor agent called Certolizumab. Though results with Crohn’s were seen in 2 week, it took 18 weeks for PBS to respond – so initial disappointment but not really since results were eventually seen.
Continue reading “Painful Bladder Syndrome (PBS) -What’s New”